The story of Alfred E. Neuman - where the name and image originated - from the creator of Mad himself, the late, great Harvey Kurtzman.
By the way - the image above is the picture that Mad Magazine sent you for 25 cents (or whatever the fee was) - which was famously "suitable for framing or wrapping fish". They ran the ad in the letters page of just about every Mad issue in the late '60s and '70s usually with some misleading headline ("None Left!" ... that's right, none left the warehouse because nobody wanted any).